Journal of Vision - Psilocybin slows binocular rivalry switching through serotonin modulation, by Carter, Pettigrew, Hasler, Wallis, & Vollenweider

Olivia Carter	Vision Sciences Lab, Harvard University, and Vision Touch & Hearing Research Centre, University of Queensland, and Neuropsychopharmacology and Brain Imaging, University of Zurich Psychiatric Hospital
Jack Pettigrew	Vision Touch & Hearing Research Centre, University of Queensland
Felix Hasler	Neuropsychopharmacology and Brain Imaging, University of Zurich Psychiatric Hospital
Guy Wallis	Perception and Motor Systems Lab, University of Queensland
Franz Vollenweider	Neuropsychopharmacology and Brain Imaging, University of Zurich Psychiatric Hospital

Binocular rivalry refers to the fluctuations in visual awareness/suppression that occur when different images are simultaneously presented to each eye. To explore the role of serotonin (5-HT) in binocular rivalry, this study investigated the affects of the hallucinogenic 5-HT1A&2A receptor agonist psilocybin (the active compound in “magic mushrooms”), alone and after pretreatment with the selective 5-HT2A antagonist ketanserin in ten healthy human subjects. Psilocybin significantly reduced the rate of binocular rivalry switching and increased the proportion of transitional/mixed percept experience. Ketanserin pretreatment blocked the majority of psilocybin's “positive” psychosis-like hallucinogenic symptoms, but had no influence on the psilocybin induced slowing of binocular rivalry switching or the “negative” symptoms associated with reduced arousal and vigilance. This finding directly links binocular rivalry switching rate to arousal and attention and suggests that psilocybin induced slowing of binocular rivalry is not 5-HT2A mediated, but instead may reflect a 5-HT1A mediated reduction of serotonin release from the brainstem raphe nuclei.