Volume 7, Number 4, Article 1, Pages 1-11 doi:10.1167/7.4.1 http://journalofvision.org/7/4/1/ ISSN 1534-7362
Simulating human cones from mid-mesopic up to high-photopic luminances
J. H. van Hateren
Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
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H. P. Snippe
Department of Neurobiophysics, University of Groningen, The Netherlands
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Abstract

A computational model of human cones for intensities ranging from 1 td up to full bleaching levels is presented. The model conforms well with measurements made in primate horizontal cells, follows Weber's law at high intensities, and performs range compression consistent with what is known of cones in other vertebrates. The model consists entirely of processes with a clear physiological interpretation: pigment bleaching, saturation of cGMP hydrolysis, calcium feedback on cGMP synthesis, and a nonlinear membrane. The model is implemented according to a very fast computational scheme useful for simulations, and sample programs in Matlab and Fortran are provided as supplementary material.

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History
Received August 28, 2006; published March 5, 2007
Citation
van Hateren, J. H., & Snippe, H. P. (2007). Simulating human cones from mid-mesopic up to high-photopic luminances. Journal of Vision, 7(4):1, 1-11, http://journalofvision.org/7/4/1/, doi:10.1167/7.4.1.
Keywords
cones, light adaptation, computational model, Weber's law, bleaching
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